Impaired glymphatic system revealed by DTI-ALPS in cerebral palsy due to periventricular leukomalacia: relation with brain lesion burden and hand dysfunction

• DOI: 10.1007/s00234-023-03269-9
• Publication Date: 2023-12-22T03:27:45Z
• Authors: Yu Yin; Ying Peng; Lisha Nie; Xianjun Li; Yaqiong Xiao; Haoxiang Jiang; Lei Gao; Heng Liu
• Keywords: Periventricular leukomalacia; Glymphatic System; Neuroradiology

Abstract Purpose Preterm children with cerebral palsy (CP) often have varying hand dysfunction, while the specific brain injury periventricular leukomalacia (PVL) cannot quite explain its mechanism. We aimed to investigate glymphatic activity using diffusion tensor image analysis along perivascular space (DTI-ALPS) method and evaluate association lesion burden dysfunction in CP secondary PVL. Methods retrospectively enrolled 18 bilateral spastic due PVL 29 age- sex-matched typically developing controls. The Manual Ability Classification System (MACS) was used assess severity of CP. A mediation model performed explore relationship among DTI-ALPS index, burden, MACS level Results There were significant differences index between their peers. lower than that controls (1.448 vs. 1.625, P = 0.003). showed fully mediated ( c ′ 0.061, 0.665), explaining 80% effect. Conclusion This study provides new insights into neural basis CP, demonstrating an important role impairment such patients. These results suggest might affect function by disrupting drainage.