Crystal sedimentation and stone formation

• DOI: 10.1007/s00240-009-0239-8
• Publication Date: 2009-12-07T19:42:54Z
• Authors: Johannes Markus B...; Beat Affolter; Rolf Meyer
• Keywords: Sedimentation

Mechanisms of crystal collision being the first step aggregation (AGN) were analyzed for calcium oxalate monohydrate (COM) directly produced in urine. COM was by titration urine seven healthy men, solutions urinary macromolecules and buffered distilled water (control). Crystal formation sedimentation followed a spectrophotometer scanning electron microscopy. Viscosity measured at 37 degrees C. From results, rate (v (S)), particle diffusion (D) incidences particles suspension (I (S)) (D)) calculated. Calculations related to average volume transit time renal collecting ducts (CD) pelvis. v (S) 0.026 +/- 0.012, UMS 0.022 0.01 control 0.091 0.02 cm min(-1) (mean SD). For urine, D 9.53 0.97 mum within 1 min can be At maximal concentration, I only 0.12 0.48 cm(-3) which, even an unrealistic permanent crystalluria, would correspond less than one collision/week/CD, whereas same tubular wall horizontal position 1.3 crystals/min stone 624 crystals/cm(2) could drop sedimentation. Sedimentation or pelvic wall, where crystals accumulate meet with tissue calcification stone, is probably essential formation. Since mainly depends on size, reducing supersaturation growth dietary restriction seems important measure prevent aggregation.