Differential diagnosis of solitary pulmonary nodules using 99mTc-3P4-RGD2 scintigraphy

• DOI: 10.1007/s00259-011-1901-2
• Publication Date: 2011-08-26T07:02:44Z
• Authors: Qingjie Ma; Bin Ji; Bing Jia; Shi Gao; Tiefeng Ji; Xueju Wang; Zhenguo Han; Guoqing Zhao
• Keywords: Solitary pulmonary nodule

Purpose Targeting of integrin ανβ3 with molecular imaging agents offers great potential in early detection and monitoring of tumour angiogenesis. Recently, an RGD (Arg-Gly-Asp) tracer, 99mTc-3P4-RGD2, with high affinity to integrin ανβ3 and in vivo tumour uptake was developed. In this study, we evaluate the feasibility of this novel radiotracer in the noninvasive differentiation of solitary pulmonary nodules (SPNs).