Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours

Male Lung Neoplasms Esophageal Neoplasms Genital Neoplasms, Female Medical Oncology Prognosis Disease-Free Survival Tumor Burden 3. Good health 03 medical and health sciences Treatment Outcome 0302 clinical medicine Fluorodeoxyglucose F18 Head and Neck Neoplasms Predictive Value of Tests Neoplasms Positron-Emission Tomography Carcinoma, Squamous Cell Humans Female Glycolysis Neoplasm Staging
DOI: 10.1007/s00259-012-2280-z Publication Date: 2012-11-13T16:30:21Z
ABSTRACT
Data available in patients suffering from squamous cell carcinoma of the head and neck, lung carcinoma, oesophageal carcinoma and gynaecological malignancies suggest that metabolic tumour volume and to a lesser extent total lesion glycolysis have the potential to become valuable in the imaging of human solid tumours as prognostic biomarkers for short- to intermediate-term survival outcomes, adding value to clinical staging, for assessment of response to treatment with neoadjuvant and concurrent chemotherapy, and for treatment optimization; for example, based on early treatment response assessment using changes in metabolic tumour volume over time, it might be possible to select patients who require a more aggressive treatment to improve their outcome. Prospective studies enrolling consecutive patients, adopting standardized protocols for FDG PET acquisition and processing, adjusting for potential confounders in the analysis (tumour size and origin) and determining the optimal methodology for determination of these novel markers are mandatory.
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