18F-alfatide PET/CT may predict short-term outcome of concurrent chemoradiotherapy in patients with advanced non-small cell lung cancer

• DOI: 10.1007/s00259-016-3505-3
• Publication Date: 2016-09-07T23:41:28Z
• Authors: Xiaohui Luan; Yong Huang; Song Gao; Xiaorong Sun; Suzhen Wang; Li Ma; Xuepeng Teng; Hong Lu; Jinming Yu; Shuanghu Yuan
• Keywords: Aged, 80 and over; Male; Lung Neoplasms; Reproducibility of Results; Chemoradiotherapy; Middle Aged; Prognosis; Peptides, Cyclic; Sensitivity and Specificity; Molecular Imaging; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Radiology Nuclear Medicine and imaging; Carcinoma, Non-Small-Cell Lung; Positron Emission Tomography Computed Tomography; Outcome Assessment, Health Care; Humans; Female; Radiopharmaceuticals; Aged

The study aims to investigate the role of 18F-alfatide positron emission tomography/computed tomography (PET/CT) in predicting the short-term outcome of concurrent chemoradiotherapy (CCRT) in patients with advanced non-small cell lung cancer (NSCLC).Eighteen patients with advanced NSCLC had undergone 18F-alfatide PET/CT scans before CCRT and PET/CT parameters including maximum and mean standard uptake values (SUVmax/SUVmean), peak standard uptake values (SUVpeak) and tumor volume (TVPET and TVCT) were obtained. The SUVmax of tumor and normal tissues (lung, blood pool and muscle) were measured, and their ratios were denoted as T/NT (T/NTlung, T/NTblood and T/NTmuscle). Statistical methods included the Two-example t test, Wilcoxon rank-sum test, Receiver-operating characteristic (ROC) curve analysis and logistic regression analyses.We found that SUVmax, SUVpeak, T/NTlung, T/NTblood and T/NTmuscle were higher in non-responders than in responders (P = 0.0024, P = 0.016, P < 0.001, P = 0.003, P = 0.004). According to ROC curve analysis, the thresholds of SUVmax, SUVpeak, T/NTlung, T/NTblood and T/NTmuscle were 5.65, 4.46, 7.11, 5.41, and 11.75, respectively. The five parameters had high sensitivity, specificity and accuracy in distinguishing non-responders and responders. Multivariate logistic regression analyses showed that T/NTlung was an independent predictor of the short-term outcome of CCRT in patients with advanced NSCLC (P = 0.032).18F-alfatide PET/CT may be useful in predicting the short-term outcome of CCRT in patients with advanced NSCLC.