Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease

• DOI: 10.1007/s00259-019-04551-w
• Publication Date: 2019-11-06T08:02:42Z
• Authors: Bixiao Cui; Tianhao Zhang; Yan Ma; Zhongwei Chen; Jie Ma; Lei Ma; Liqun Jiao; Yun Zhou; Baoci Shan; Jie Lu
• Keywords: Adult; Male; Middle Cerebral Artery; Middle Aged; Magnetic Resonance Imaging; 3. Good health; 03 medical and health sciences; Glucose; 0302 clinical medicine; Ischemia; Cerebrovascular Circulation; Positron-Emission Tomography; Humans; Original Article; Female; Carotid Artery, Internal

Abstract Purpose Cerebral blood flow (CBF) and glucose metabolism are important significant factors in ischaemic cerebrovascular disease. The objective of this study was to use quantitative hybrid PET/MR evaluate the effects surgery treatment on symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive Methods Fifteen patients diagnosed with disease were evaluated using a TOF system (Signa, GE Healthcare). CBF value measured by arterial spin labelling (ASL) standardized uptake ratio (SUVR) 18 F-FDG PET obtained, except for infarct area its contralateral side, before after bypass surgery. asymmetry index (AI) calculated from SUVR ipsilateral hemispheres, respectively. ΔCBF ΔSUVR as percent changes between surgery, paired t tests used determine whether change occurred. Spearman’s rank correlation also compare same region. Results analysis primarily revealed that statistically increase occurred affected side ( P < 0.01). postprocedural not significantly higher than preprocedural > 0.05). However, AI values lower A found preoperative hemisphere Conclusions present demonstrates combination ASL could be simultaneously analyse patients’ haemodynamic patterns superficial temporal artery-middle (STA-MCA) This therefore represents an essential tool evaluation critical metabolic status