Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)

• DOI: 10.1007/s00259-019-04586-z
• Publication Date: 2019-12-09T03:02:35Z
• Authors: Pauline T. Lukey; Christopher Coello; Roger Gunn; Christine Parker; Frederick J. Wilson; Azeem Saleem; Nadia Garman; Maria Costa; Stuart Kendrick; Mayca Onega; Arthur R. Kang’ombe; Allan Listanco; James Davies; Joaquim Ramada-Ma...; Sara Moz; William A. Fahy; Toby M. Maher; Gisli Jenkins; Jan Passchier; Richard P. Marshall
• Keywords: Standardized uptake value; Pathogenesis

The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation transforming growth factor beta (TGFβ). This study sought to quantify expression αvβ6 lungs healthy humans and subjects with using αvβ6-selective [