Defining the optimal target-to-background ratio to identify positive lymph nodes in prostate cancer patients undergoing robot-assisted [99mTc]Tc-PSMA radioguided surgery: updated results and ad interim analyses of a prospective phase II study

• DOI: 10.1007/s00259-024-06789-5
• Publication Date: 2024-06-11T04:01:30Z
• Authors: Leonardo Quarta; Elio Mazzone; Donato Cannoletta; Armando Stabile; Simone Scuderi; Francesco Barletta; Vito Cucchiara; Luigi Nocera; Antony Pellegrino; Daniele Robesti; Riccardo Leni; Paolo Zaurito; Giorgio Brembilla; Francesco De Cobelli; Ana Maria Samanes...; Maria Picchio; Arturo Chiti; Francesco Montorsi; Alberto Briganti; Giorgio Gandaglia
• Keywords: Glutamate carboxypeptidase II; Interim

Prostate-specific membrane antigen radioguided surgery (PSMA-RGS) might identify lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing extended pelvic dissection (ePLND). The optimal target-to-background (TtB) ratio to define RGS positivity is still unknown.