Predicting the pathological response to chemoradiotherapy of non-mucinous rectal cancer using pretreatment texture features based on intravoxel incoherent motion diffusion-weighted imaging

• DOI: 10.1007/s00261-019-02032-0
• Publication Date: 2019-04-27T07:45:13Z
• Authors: Siye Liu; Lu Wen; Jing Hou; Shaolin Nie; Jumei Zhou; Fang Cao; Qiang Lu; Yuhui Qin; Yi Fu; Xiaoping Yu
• Keywords: Intravoxel incoherent motion; Chemoradiotherapy

To investigate the performance of mean parametric values and texture features based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) identifying pathological complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Pretreatment IVIM-DWI was performed 41 LARC patients receiving nCRT this prospective study. The parameters (apparent diffusion coefficient, ADC; pure D; pseudo-diffusion D* perfusion fraction, f), first-order, gray-level co-occurrence matrix (GLCM) were compared between pCR (n = 9) non-pathological responder (non-pCR, n 32) groups. Receiver operating characteristic (ROC) curves univariate multivariate logistic regression analysis generated determine efficiency for pCR. first-order did not show significant differences non-pCR group had lower Contrast DifVarnc extracted from ADC, D, maps, respectively, as well CorrelatD value. Higher CorrelatD*, Correlatf, SumAvergADC, SumAvergD observed group. area under ROC curve (AUC) individual predictors ranged 0.698 0.837, with sensitivities 43.75% 87.50% specificities 66.67 100.00%. In analysis, CorrelatD* (P < 0.001), DifVarncADC 0.024), DifVarncD 0.001) independent pCR, an AUC 0.986, a sensitivity 93.75%, specificity GLCM may be potential approach identify LARC.