Can [18F]F-FDG PET/CT be used to assess the pre-operative extent of peritoneal carcinomatosis in patients with colorectal cancer?

• DOI: 10.1007/s00261-019-02268-w
• Publication Date: 2019-10-23T16:06:56Z
• Authors: Fortuné M. K. Ele...; Bas Starremans; Sander Thomas Lau...; Andreas J. A. Bre...; Johannes H. W. de...; Linda Heijmen; Lioe-Fee de Geus-Oei
• Keywords: Male; [F]fluorodeoxyglucose positron emission tomography; Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences; Radboud University Medical Center; Radboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences; Radiation Dosage; 03 medical and health sciences; 0302 clinical medicine; SDG 3 - Good Health and Well-being; Fluorodeoxyglucose F18; Positron Emission Tomography Computed Tomography; Medical Imaging - Radboud University Medical Center; Humans; Peritoneal Neoplasms; Retrospective Studies; HIPEC; [F-18]fluorodeoxyglucose positron emission tomography; Middle Aged; Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health Sciences; Colorectal cancer; 3. Good health; Preoperative Period; Female; Radiopharmaceuticals; Colorectal Neoplasms; Peritoneal carcinomatosis; Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences; Surgery - Radboud University Medical Center

Abstract Purpose To evaluate whether PET/CT could be used to assess the extent of colorectal peritoneal metastases. Methods All patients who underwent a scan before CRS-HIPEC procedure between January 1, 2010 and December 31, 2013 were retrospectively included ( n = 35). Two nuclear medicine physicians (observer 1 observer 2) separately reviewed scans on intraperitoneal abnormalities. A simplified PCI was compare rPCI versus sPCI. Results Included had median age 60.6 years. Histology primary tumors 51.5% adenocarcinomas, 37.1% mucinous adenocarcinoma, 11.4% SRCC. Median sPCI 9.5 (5.0–11.8) 5.0 (3.0–7.0) for 4.0 (3.0–6.0) 2 p 0.02 0.01, respectively). When compared surgical data, showed poor correlation assessing PC both adenocarcinoma rho – 0.17, 0.51 0.13, 0.61) as well carcinoma or SRCC 0.44, 0.08 0.38, 0.14). Conclusion underestimates during surgery in non-mucinous CRC is not recommended tumor scoring.