Estimation of differential renal function on routine abdominal imaging employing compressed-sensed contrast-enhanced MR: a feasibility study referenced against dynamic renal scintigraphy in patients with deteriorating renal retention parameters

• DOI: 10.1007/s00261-023-03823-2
• Publication Date: 2023-02-02T18:04:27Z
• Authors: Victor Schulze-Za...; David J. Winkel; Felix Kaul; Theo Demerath; Silke Potthast; Tobias J. Heye; Daniel T. Boll
• Keywords: Renal cortex; Dynamic Contrast-Enhanced MRI

To assess whether high temporal/spatial resolution GRASP MRI acquired during routine clinical imaging can identify several degrees of renal function impairment referenced against dynamic scintigraphy.This retrospective study consists method development and verification parts. During development, patients subject to using gadoterate meglumine post-contrast technique (TR/TE 3.3/1.6 ms; FoV320 × 320 mm; FA12°; Voxel1.1 1.1x2.5 mm) were matched into four equally-sized groups (no-mild-moderate-severe impairment) according their laboratory-determined estimated glomerular filtration rates (eGFR); 60|120 patients|kidneys included. Regions-of-interest (ROIs) placed on cortices, medullary pyramids collecting systems bilateral kidneys. Cortical perfusion, tubular concentration system excretion determined as TimeCortex=Pyramid(sec), SlopeTubuli (sec-1), TimeCollecting System (sec), respectively, measured by a combination extraction time intensity curves respective quantitative parameters. For verification, scintigraphy (99mTc-MAG3, 100 MBq/patient) three (no-mild/moderate-severe impairment). Split parameters post 1.5-2.5 min well MAG3 TER correlated with retrieved technique; 15|30 included.Method showed differing values for TimeCortex=Pyramid(71|75|93|122 s), SlopeTubuli(2.6|2.1|1.3|0.5 s-1) System(90|111|129|139 s) the partial significant tendencies (several p-values < 0.001). In 29/30 kidneys (96.7%) assigned correct group.High temporal spatial MR allows degree accuracy.