Diagnostic accuracy and reliability of CT-based Node-RADS for colon cancer

• DOI: 10.1007/s00261-024-04485-4
• Publication Date: 2024-07-08T08:01:51Z
• Authors: Jakob Leonhardi; Matthias Mehdorn; Sigmar Stelzner; Uwe Scheuermann; Anne-Kathrin Höhn; Daniel Seehofer; Benedikt Schnarko...; Timm Denecke; Hans-Jonas Meyer
• Keywords: Kappa

Abstract Objective The Node-RADS classification was recently published as a system to better characterize lymph nodes in oncological imaging. present analysis investigated the diagnostic benefit of staging computed tomography (CT) images categorize and stage patients with colon cancer. Materials methods All were surgically resected histopathological analyzed. scored accordance by two experienced radiologists. Interreader variability assessed Cohen’s kappa analysis, discrimination performed Mann-Whitney-U test accuracy receiver-operating characteristics (ROC) curve analysis. Results Overall, 108 ( n = 49 females, 45.3%) mean age 70.08 ± 14.34 years included. In total score showed statistically significant differences between N- N + (for reader 1: 1.89 1.09 for versus 2.93 1.62 N+, 2: 1.33 0.48 3.65 0.94 p 0.001, respectively). ROC node an area under 0.68. A threshold value 2 resulted sensitivity 0.62 specificity 0.71. Conclusion derived from CT shows only limited correctly predict nodal positivity interreader seems be high should question clinical translation this tumour entity.