2011: the immune hallmarks of cancer

• DOI: 10.1007/s00262-010-0968-0
• Publication Date: 2011-01-25T13:07:41Z
• Authors: Federica Cavallo; Carla De Giovanni; Patrizia Nanni; Guido Forni; Pier-Luigi Lollini
• Keywords: Cancer Research; Cancer, Inflammation, Immune surveillance, Immune suppression, Oncoantigens, Tumor vaccine, Antitumor antibodies; Immunology; Symposium-In-Writing; Cancer Vaccines; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Oncology; Neoplasms; Immunology and Allergy; Humans; CANCER; IMMUNE SYSTEM

Ten years after the publication of position paper "The hallmarks cancer" (Hanahan and Weinberg Cell 100:57-70, 2000), it has become increasingly clear that mutated cells on their way to giving rise a tumor have also learn how thrive in chronically inflamed microenvironment, evade immune recognition, suppress reactivity. Genetic molecular definition these three cancer offers opportunity deploy specific countermeasures reverse situation favor system and, eventually, patient. This new information could be channeled address what seem major for control progression: effective procedures activate reactivity; characterization not-disposable oncoantigens; counteraction suppression.