Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma

• DOI: 10.1007/s00262-023-03487-3
• Publication Date: 2023-07-18T16:02:03Z
• Authors: Paola Lasso; Laura Rojas; Cindy Arévalo; Claudia Urueña; Natalia Murillo; Paula Nossa; Tito Sandoval; Luis Carlos Chitiva; Alfonso Barreto; Geison M. Costa; Susana Fiorentino
• Keywords: Plant Extracts; Research; Melanoma, Experimental; Immunity; Breast Neoplasms; CD8-Positive T-Lymphocytes; 3. Good health; Mice; Disease Models, Animal; Tumor Microenvironment; Humans; Animals; Female; Piper nigrum

Abstract Although the antitumor effect of P. nigrum has been widely studied, research related to its possible immunomodulatory effects is relatively scarce. Here, and activity an ethanolic extract were evaluated in murine models 4T1 breast cancer B16-F10 melanoma. In vitro evaluations showed that cytotoxic activity, induces apoptotic cell death, a pro-oxidant both lines, but it regulates glucose uptake differently decreasing not B16-F10. significantly reduced tumor size decreased occurrence macrometastases model. Evaluation immune subpopulations by flow cytometry revealed increases frequency dendritic cells activated CD8 + T decreases myeloid-derived suppressor like Tregs microenvironment with different dynamics. Our findings strongly suggest exerts functions, slightly modulation cellular energy metabolism, which could ultimately contribute promising .