Clonal expansion of shared T cell receptors reveals the existence of immune commonality among different lesions of synchronous multiple primary lung cancer

• DOI: 10.1007/s00262-024-03703-8
• Publication Date: 2024-04-26T11:01:38Z
• Authors: Yadong Wang; Zhicheng Huang; Bowen Li; Jianchao Xue; Chao Guo; Zhongxing Bing; Zhibo Zheng; Yang Song; Yuan Xu; Guanghua Huang; Haochen Li; Xiaoqing Yu; Yankai Xia; Ruirui Li; Xiaoyan Si; Li Zhang; Ji Li; Lan Song; Yuanyuan Xiong; Dejian Gu; Mengmeng Song; Zhipeng Zhou; Rongrong Chen; Zhe Feng; Zhixin Bie; Xiaoguang Li; Huaxia Yang; Shanqing Li; Naixin Liang
• Keywords: Pathogenesis

The increase in the detection rate of synchronous multiple primary lung cancer (MPLC) has posed remarkable clinical challenges due to limited understanding its pathogenesis and molecular features. Here, comprehensive comparisons genomic immunologic features between MPLC solitary nodule (SN), as well different lesions same patient, were performed. Compared with SN, displayed a lower EGFR mutation but higher rates BRAF, MAP2K1, MTOR mutation, which function exactly upstream downstream signaling pathway. Considerable heterogeneity T cell receptor (TCR) repertoire exists among not only patients also patient. Invasive exhibited significantly TCR diversity expansion than those SN. Intriguingly, patient always shared certain proportion clonotypes. Significant clonal could be observed clonotypes, particularly existing all In conclusion, this study provided evidences distinctive mutational landscape, activation oncogenic pathways, compared significant clonotypes demonstrated existence immune commonality shed new light on individually tailored precision therapy for MPLC.