TRP-2 / gp100 DNA vaccine and PD-1 checkpoint blockade combination for the treatment of intracranial tumors

• DOI: 10.1007/s00262-024-03770-x
• Publication Date: 2024-07-02T14:03:38Z
• Authors: Joshua R. D. Pearson; Carles Puig-Saenz; Jubini E. Thomas; Lydia D. Hardowar; Murrium Ahmad; Louise C. Wainwright; Adam M. McVicar; Victoria A. Brent...; Chris J. Tinsley; A. Graham Pockley; Lindy G. Durrant; Stephanie E. B. M...
• Keywords: Pentamer; Immune checkpoint

Intracranial tumors present a significant therapeutic challenge due to their physiological location. Immunotherapy presents an attractive method for targeting these intracranial relatively low toxicity and tumor specificity. Here we show that SCIB1, TRP-2 gp100 directed ImmunoBody® DNA vaccine, generates strong specific immune response, as demonstrated by the high number of TRP2-specific IFNγ spots produced detection pentamer positive T cells in spleen vaccinated mice. Furthermore, vaccine-induced were able recognize kill B16