Pre-injection of exosomes can significantly suppress ovarian cancer growth by activating the immune system in mice

• DOI: 10.1007/s00262-025-03951-2
• Publication Date: 2025-02-04T17:36:05Z
• Authors: Yuanyuan Wang; Changyi Zhang; Huimin Zeng; Liangliang Wang; Zanhong Wang; Zhiqiang Han
• Keywords: Ovarian cancer; Tumor immune microenvironment; Research; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Immunotherapy; Exosomes; RC254-282

As a type of "cold tumor" with limited immune cell infiltration, ovarian cancer has historically shown efficacy in immunotherapy. In this study, we report that exosomes from can specifically target omentum which is the predilection site for to metastasize and combat subsequently implanted tumor. Furthermore, found substantial increase proportion CD3 + T cells, particularly CD8 within omental tissue where homed. This was accompanied by significant enhancement granzyme B levels cells. Additionally, there notable elevation concentration interferon-gamma (IFN-γ) peripheral blood. vitro results indicated could be internalized dendritic cells (DCs), promote DC differentiation, induce production IFN-γ Surprisingly, also observed high expression programmed death ligand 1 (PD-L1) omentum. Therefore, discovered whether combining PD-L1 blockade led further tumor regression. However, although combination group showed complete regression, difference did not reach statistical significance. But general, emphasize case pre-injection, have great potential famous tumor", cancer, via targeting activating anti-tumor immunity, offering novel avenue overcoming cancer.