Factors Predicting a Good Symptomatic Outcome After Prostate Artery Embolisation (PAE)

• DOI: 10.1007/s00270-018-1912-5
• Publication Date: 2018-02-26T21:55:59Z
• Authors: D. Maclean; M. Harris; T. Drake; B. Maher; S. Modi; J. Dyer; B. Somani; N. Hacking; T. Bryant
• Keywords: Aged, 80 and over; Male; Prostatic Diseases; Computed Tomography Angiography; Prostate; 610; Angiography, Digital Subtraction; Arterial Occlusive Diseases; Organ Size; Middle Aged; Embolization, Therapeutic; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Prospective Studies; Aged

As prostate artery embolisation (PAE) becomes an established treatment for benign prostatic obstruction, factors predicting good symptomatic outcome remain unclear. Pre-embolisation prostate size as a predictor is controversial with a handful of papers coming to conflicting conclusions. We aimed to investigate if an association existed in our patient cohort between prostate size and clinical benefit, in addition to evaluating percentage volume reduction as a predictor of symptomatic outcome following PAE.Prospective follow-up of 86 PAE patients at a single institution between June 2012 and January 2016 was conducted (mean age 64.9 years, range 54-80 years). Multiple linear regression analysis was performed to assess strength of association between clinical improvement (change in IPSS) and other variables, of any statistical correlation, through Pearson's bivariate analysis.No major procedural complications were identified and clinical success was achieved in 72.1% (n = 62) at 12 months. Initial prostate size and percentage reduction were found to have a significant association with clinical improvement. Multiple linear regression analysis (r2 = 0.48) demonstrated that percentage volume reduction at 3 months (r = 0.68, p < 0.001) had the strongest correlation with good symptomatic improvement at 12 months after adjusting for confounding factors.Both the initial prostate size and percentage volume reduction at 3 months predict good symptomatic outcome at 12 months. These findings therefore aid patient selection and counselling to achieve optimal outcomes for men undergoing prostate artery embolisation.