End-hole Versus Microvalve Infusion Catheters in Patients Undergoing Drug-Eluting Microspheres-TACE for Solitary Hepatocellular Carcinoma Tumors: A Retrospective Analysis

• DOI: 10.1007/s00270-018-2150-6
• Publication Date: 2019-01-11T12:07:45Z
• Authors: Joseph J. Titano; Aaron M. Fischman; Arnav Cherian; Madeline Tully; Lance L. Stein; Louis Jacobs; Raymond A. Rubin; Michael Bosley; Steve Citron; Dean W. Joelson; Roshan Shrestha; Aravind Arepally
• Keywords: Adult; Male; Carcinoma, Hepatocellular; Premedication; Antineoplastic Agents; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Humans; Clinical Investigation; Chemoembolization, Therapeutic; Aged; Retrospective Studies; Liver Neoplasms; Equipment Design; Middle Aged; Microspheres; Liver Transplantation; 3. Good health; Survival Rate; Treatment Outcome; Female; Neoplasm Recurrence, Local; Vascular Access Devices

Pre-transplant locoregional therapy for hepatocellular carcinoma (HCC) during bridge-to-transplant impacts recurrence and survival rates following liver transplantation. Optimizing the effectiveness of transarterial chemoembolization (TACE) in this population is imperative, microvalve infusion catheters offer a means such improvement. All treatment-naive patients with solitary HCC tumors < 6.5 cm who underwent drug-eluting microspheres (DEM) TACE between 04/2015 08/2017 were retrospectively reviewed. Eighty-eight included DEM-TACE either standard end-hole (EH) or (MVI). The EH (n = 70) MVI 18) cohorts had similar baseline tumor size, laboratory values, etiologies. Initial objective response significantly higher vs. (100% 76.5%, p 0.019). There was no difference adverse events groups (p 0.265). exhibited lower AST 0.003) ALT 0.044) at 6 months. Blinded pathological analysis explanted livers showed greater concentrations within relative to surrounding tissue explants (88.7 ± 10.6%) versus (55.3 32.7%) 0.002). percentage necrosis group (89.0 2.2%) compared (56.1 44.5%) 0.006). In retrospective study single-center cohort, procedures associated improved response, increased deposition tissue, explant those performed using catheters.