Profiling of bacterial bloodstream infections in hematological and oncological patients based on a comparative survival analysis

• DOI: 10.1007/s00277-021-04541-9
• Publication Date: 2021-05-03T22:11:53Z
• Authors: Sarah Weber; Aaron Magh; Michael Hogardt; Volkhard A. J. Kempf; Maria J. G. T. Ve...; Hubert Serve; Sebastian Scheich; Björn Steffen
• Keywords: Bloodstream infection; Bacteremia; Hematology; Medical microbiology

Abstract Bloodstream infections (BSI) are a frequent complication in patients with hematological and oncological diseases. However, the impact of different bacterial species causing BSI multiple remains incompletely understood. We performed retrospective study profiling 637 episodes patients. Based on 30-day (30d) overall survival (OS), we analyzed types grouped BSI-associated bacteria into clusters followed by further assessment clinical infection-related characteristics. discovered that polymicrobial (different organisms first day episode) sequential (another before respective were associated worse 30d OS. Different groups could be classified three outcome based OS: favorable (FAV) including mainly common skin contaminants, Escherichia spp. Streptococcus spp.; intermediate (INT) Enterococcus spp., vancomycin-resistant multidrug-resistant gram-negative (MDRGN); adverse (ADV) MDRGN an additional carbapenem-resistance (MDRGN+CR). A or especially influenced combination two INT cluster BSI. The presence assignment identified as independent risk factors for mortality Cox multivariate regression analysis. to differentiated perspective open new insights prognosis should validated other patient cohorts.