The anemia-independent impact of myelodysplastic syndromes on health-related quality of life

• DOI: 10.1007/s00277-021-04654-1
• Publication Date: 2021-09-03T15:28:50Z
• Authors: Hanneke J. C. M. ...; Annette Conrads-F...; Karin A. Koinig; Alex Smith; Ge Yu; Theo de Witte; Bruce H. R. Wolff...; Gerwin Huls; Uwe Siebert; Reinhard Stauder; Melanie M. van de...
• Keywords: Depression

Abstract Myelodysplastic syndromes (MDS) are in the majority of cases characterized by anemia. Both anemia and MDS per se may directly contribute to impairments health-related quality life (HRQoL). In this study, we aimed investigate anemia-independent impact on HRQoL. We evaluated participants (≥ 50 years) from large population-based Lifelines cohort ( N = 44,694, mean age 59.0 ± 7.4 years, 43.6% male) European Registry (EUMDS) 1538, 73.4 9.0 63.0% male), which comprises a lower-risk patients. To enable comparison concerning HRQoL, SF-36 scores measured were converted EQ-5D-3L index (range 0–1) dimension scores. Lower-risk patients had significantly lower HRQoL than those cohort, as illustrated both score five different dimensions. Multivariable linear regression analysis demonstrated that an adjusted total EQ-5D (B − 0.12, p < 0.001) “direct” 0.10, 0.001). logistic revealed mobility, self-care, usual activities, anxiety/depression (all except pain/discomfort). This study demonstrates major part negative is not mediated via Thus, therapeutic focus should include treatment strategies directed at underlying pathogenic mechanisms improve rather aiming predominantly increasing hemoglobin levels.