The validation of advanced-stage Hodgkin lymphoma international prognostic index (A-HIPI) in Turkish patients with classical Hodgkin lymphoma

• DOI: 10.1007/s00277-025-06292-3
• Publication Date: 2025-03-12T01:34:06Z
• Authors: Oguzhan Koca; Berk Ozyurt; Aysenur Umar; Deniz Ozmen; Tugrul Elverdi; Ayse Salihoglu; Muhlis Cem Ar; Zafer Baslar; Ahmet Emre Eskazan
• Keywords: Concordance; Akaike information criterion; International Prognostic Index; Progression-free survival; Hematology

Abstract In advanced-stage classical Hodgkin lymphoma (cHL), the prognosis has improved due to combination chemotherapy and PET/CT-guided treatment modification, resulting in a decreased prognostic capacity of IPS models. A novel model, A-HIPI, was found be superior predicting prognosis. this study, we aimed validate A-HIPI model among Turkish cHL patients compare its performance with other clinical prediction We retrospectively evaluated diagnosed between 2005 2018 at Istanbul University-Cerrahpaşa. used IPS-7, IPS-3, scores calculate C-index (Harrell’s Concordance Index) for discrimination; calibration intercept, slope calibration. The models were compared using Akaike’s Information Criterion (AIC). Two hundred seven enrolled median follow-up 75 months, 37 (17.9%) died. 5-year PFS OS 66.6% 84.9%, respectively. All three OS. well-calibrated aged ≤65 years, but not calibrated > 65 years. With respective 0.605 0.740; whereas, IPS-7 it 0.598 0.684, IPS-3 0.624 0.705. lowest AIC value observed A-HIPI. IPS-3. This study validated homogeneous patient group protocol, all follow-ups performed single center after early 2000s Turkey. demonstrated better than models, except new is needed as are out date been group.