Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

• DOI: 10.1007/s00330-003-2051-0
• Publication Date: 2004-03-15T12:44:58Z
• Authors: Bettina Sorger; Ralf Girnus; Oliver Schulte; Barbara Krug; Klaus Lackner; Volker Sturm; J�rgen Bunke; Volker Hesselmann; Kathrin Lasek; Mohammad Maarouf; Christoph Wedekind
• Keywords: Subthalamic Nucleus; Neuroradiology

This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.