Internal structures of the globus pallidus in patients with Parkinson’s disease: evaluation with quantitative susceptibility mapping (QSM)

• DOI: 10.1007/s00330-014-3472-7
• Publication Date: 2014-10-31T19:42:48Z
• Authors: Satoru Ide; Shingo Kakeda; Issei Ueda; Keita Watanabe; Yu Murakami; Junji Moriya; Atsushi Ogasawara; Koichiro Futatsuya; Toru Sato; Norihiro Ohnari; Kazumasa Okada; Atsuji Matsuyama; Hitoshi Fujiwara; Masanori Hisaoka; Sadatoshi Tsuji; Tian Liu; Yi Wang; Yukunori Korogi
• Keywords: Aged, 80 and over; Male; Observer Variation; Brain Mapping; Parkinson Disease; Middle Aged; Globus Pallidus; Magnetic Resonance Imaging; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Prospective Studies; Aged

The aim of this study was to assess the susceptibility change in medial and lateral globus pallidus (GPm and GPl) related to age separately, using quantitative susceptibility mapping (QSM) and to determine whether QSM can depict GPm in Parkinson's disease (PD) patients.QSM was performed in 19 PD patients and in 41 normal control (NC) subjects. First, we quantitatively analysed age-related changes in QSM value in NC for GPl and GPm by a manual region of interest (ROI) technique. Then, in PD patients and age-matched NC subjects, we evaluated the depiction of GPm on QSM images qualitatively.In NC, the QSM value within GPl significantly increased gradually with age (r = 0.32, p = 0.04), whereas it did not change with age in GPm. The average QSM value was significantly larger for GPl than for GPm (205 vs 191, p < 0.05). In both PD patients and age-matched NC, the depiction of GPm on QSM images was good in most cases (87 %, 33 of 38 sides in PD patients) mainly because of the differences in susceptibility between GPm and GPl.The QSM value in GPl increases gradually with age, which allows for the identification of GPm in elderly PD subjects.