Aberrant functional connectivity of default-mode network in type 2 diabetes patients

• DOI: 10.1007/s00330-015-3746-8
• Publication Date: 2015-04-22T06:14:22Z
• Authors: Ying Cui; Yun Jiao; Hua-Jun Chen; Jie Ding; Bing Luo; Cheng-Yu Peng; Sheng-Hong Ju; Gao-Jun Teng
• Keywords: Posterior cingulate; Neurocognitive; Neuroradiology

Type 2 diabetes mellitus is associated with increased risk for dementia. Patients impaired cognition often show default-mode network disruption. We aimed to investigate the integrity of a in diabetic patients by using independent component analysis, and explore relationship between abnormalities, neurocognitive performance variables. Forty-two type 42 well-matched healthy controls were included underwent resting-state functional MRI 3 Tesla unit. Independent analysis was adopted extract network, including its anterior posterior components. Z-maps both sub-networks compared two groups correlated each clinical variable. showed connectivity around medial prefrontal cortex sub-network, but decreased cingulate sub-network. The part significantly score on Complex Figure Test-delay recall test (r = 0.359, p 0.020), time spent Trail-Making Test-part B -0.346, 0.025) insulin resistance level −0.404, 0.024). Dissociation pattern found patients, which might provide powerful new insights into neural mechanisms that underlie diabetes-related cognitive decline. • Default- mode plays central role maintaining normal Network within default disrupted Decreased Disrupted explain population