Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue

• DOI: 10.1007/s00330-016-4654-2
• Publication Date: 2016-11-10T13:58:23Z
• Authors: Gregor Jost; Thomas Frenzel; Jessica Lohrke; Diana Constanze L...; Shinji Naganawa; Hubertus Pietsch
• Keywords: Infiltration (HVAC)

Signal hyperintensity on unenhanced MRI in certain brain regions has been reported after multiple administrations of some, but not all, gadolinium-based contrast agents (GBCAs). One potential initial pathway GBCA entry into the brain, infiltration from blood cerebrospinal fluid (CSF), was systematically evaluated this preclinical study. and distribution CSF were investigated healthy rats using repeated fluid-attenuated up to 4 h high-dose (1.8 mmol/kg) administration six marketed one experimental GBCA. Additionally, gadolinium measurements CSF, tissue samples (after 24 h) performed inductively coupled plasma mass spectrometry. Enhanced signals spaces with similar kinetics observed for all GBCAs. No substantial differences concentrations among GBCAs found or tissue. After 4.5 h, concentration clearly higher than almost completely cleared lower h. In signal hyperintensities, no penetration exist • Gadolinium-based can cross blood-CSF barrier. Fluid-attenuated shows flow. structure physicochemical properties do impact distribution. clearance complete within rats. is a brain.