Automated MR-based lung volume segmentation in population-based whole-body MR imaging: correlation with clinical characteristics, pulmonary function testing and obstructive lung disease

• DOI: 10.1007/s00330-018-5659-9
• Publication Date: 2018-08-27T08:27:24Z
• Authors: Jan Mueller; Stefan Karrasch; Roberto Lorbeer; Tatyana Ivanovska; Andreas Pomschar; Wolfgang G. Kunz; Ricarda von Krüchten; Annette Peters; Fabian Bamberg; Holger Schulz; Christopher L. Sc...
• Keywords: Male; Vital Capacity; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Magnetic Resonance Imaging ; Whole-body Imaging ; Computer-assisted Image Analysis ; Pulmonary Function Test ; Obstructive Lung Disease; Forced Expiratory Volume; Image Processing, Computer-Assisted; Humans; Prospective Studies; Lung; Aged; Smoking; Total Lung Capacity; Middle Aged; Magnetic Resonance Imaging; Respiratory Function Tests; 3. Good health; Residual Volume; Spirometry; Case-Control Studies; Female; Lung Volume Measurements; Algorithms

Whole-body MR imaging is increasingly utilised; although for lung dedicated sequences are often not included, the chest is typically imaged. Our objective was to determine the clinical utility of lung volumes derived from non-dedicated MRI sequences in the population-based KORA-FF4 cohort study.400 subjects (56.4 ± 9.2 years, 57.6% males) underwent whole-body MRI including a coronal T1-DIXON-VIBE sequence in inspiration breath-hold, originally acquired for fat quantification. Based on MRI, lung volumes were derived using an automated framework and related to common predictors, pulmonary function tests (PFT; spirometry and pulmonary gas exchange, n = 214) and obstructive lung disease.MRI-based lung volume was 4.0 ± 1.1 L, which was 64.8 ± 14.9% of predicted total lung capacity (TLC) and 124.4 ± 27.9% of functional residual capacity. In multivariate analysis, it was positively associated with age, male, current smoking and height. Among PFT indices, MRI-based lung volume correlated best with TLC, alveolar volume and residual volume (RV; r = 0.57 each), while it was negatively correlated to FEV1/FVC (r = 0.36) and transfer factor for carbon monoxide (r = 0.16). Combining the strongest PFT parameters, RV and FEV1/FVC remained independently and incrementally associated with MRI-based lung volume (β = 0.50, p = 0.04 and β = - 0.02, p = 0.02, respectively) explaining 32% of the variability. For the identification of subjects with obstructive lung disease, height-indexed MRI-based lung volume yielded an AUC of 0.673-0.654.Lung volume derived from non-dedicated whole-body MRI is independently associated with RV and FEV1/FVC. Furthermore, its moderate accuracy for obstructive lung disease indicates that it may be a promising tool to assess pulmonary health in whole-body imaging when PFT is not available.• Although whole-body MRI often does not include dedicated lung sequences, lung volume can be automatically derived using dedicated segmentation algorithms • Lung volume derived from whole-body MRI correlates with typical predictors and risk factors of respiratory function including smoking and represents about 65% of total lung capacity and 125% of the functional residual capacity • Lung volume derived from whole-body MRI is independently associated with residual volume and the ratio of forced expiratory volume in 1 s to forced vital capacity and may allow detection of obstructive lung disease.