Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis

• DOI: 10.1007/s00330-019-06263-z
• Publication Date: 2019-05-22T21:25:06Z
• Authors: Ferdinand Roski; Johannes Hammel; Kai Mei; Thomas Baum; Jan S. Kirschke; Alexis Laugerette; Felix K. Kopp; Jannis Bodden; Daniela Pfeiffer; Franz Pfeiffer; Ernst J. Rummeny; Peter B. Noël; Alexandra S. Gersing; Benedikt J. Schwa...
• Keywords: Neuroradiology

To investigate the in vivo applicability of non-contrast-enhanced hydroxyapatite (HA)-specific bone mineral density (BMD) measurements based on dual-layer CT (DLCT).A spine phantom containing three artificial vertebral bodies with known HA densities was measured to obtain spectral data using DLCT and quantitative (QCT), simulating different patient positions grades obesity. BMD calculated from virtual monoenergetic images at 50 200 keV. HA-specific values 174 vertebrae 33 patients (66 ± 18 years; 33% women) were determined non-contrast routine compared corresponding QCT-based values.Examining phantom, a par QCT measurements. In revealed strong correlations between (r = 0.987 [95% confidence interval, 0.963-1.000]; p < 0.001) substantial agreement Bland-Altman plot.DLCT-based comparable analyses. This suggests that opportunistic DLCT-based are an alternative QCT, without requiring phantoms specific protocols.• hydroxyapatite-specific show vivo. • Opportunistic may be feasible for dedicated examination protocols or phantom.