Standardized measurement of abdominal muscle by computed tomography: association with cardiometabolic risk in the Framingham Heart Study

• DOI: 10.1007/s00330-022-08934-w
• Publication Date: 2022-07-02T06:03:03Z
• Authors: Andreas Kammerlander; Asya Lyass; Taylor F. Mahoney; Jana Taron; Parastou Eslami; Michael T. Lu; Michelle T. Long; Ramachandran S. V...; Joseph M. Massaro; Udo Hoffmann
• Keywords: Framingham Heart Study

To provide a standard for total abdominal muscle mass (TAM) quantification on computed tomography (CT) and investigate its association with cardiovascular risk in primary prevention setting.We included 3016 Framingham Heart Study participants free of disease (CVD) who underwent CT between 2002 2005. On single slice at the level L3/L4, we segmented (1) TAM-Area, (2) TAM-Index (= TAM-Area/height) and, (3) TAM-Fraction TAM-Area/total cross-sectional CT-area). We tested these measures prevalent incident cardiometabolic factors CVD events during follow-up 11.0 ± 2.7 years.In this community-based sample (49% women, mean age: 50.0 10.0 years), all quantity were significantly associated events. However, only remained key outcomes (e.g., adj. OR 0.68 [0.55, 0.84] HR 0.73 [0.57, 0.92] hypertension events, respectively) after adjustment age, sex, body index, waist circumference. Moreover, higher was lower OR: 0.56 [0.36-0.89] diabetes versus TAM-Area: 1.26 [0.79-2.01] TAM-Index: 1.09 [0.75-1.58]).TAM-Fraction L3/L4 is novel composition marker setting that has potential to improve stratification beyond traditional obesity.• In analysis (n = 3016), TAM-F more closely as compared TAM alone or indexed surface area. • could serve measure prediction.