Effect of smoking on the diagnostic results and complication rates of percutaneous transthoracic needle biopsy

• DOI: 10.1007/s00330-024-10705-8
• Publication Date: 2024-03-25T21:40:13Z
• Authors: Woo Hyeon Lim; Jong Hyuk Lee; Hyungin Park; Chang Min Park; Soon Ho Yoon
• Keywords: Interquartile range; Interventional radiology

Abstract Objective To investigate the association of smoking with outcomes percutaneous transthoracic needle biopsy (PTNB). Methods In total, 4668 PTNBs for pulmonary lesions were retrospectively identified. The associations status (never, former, current smokers) and intensity (≤ 20, 21–40, > 40 pack-years) diagnostic results (malignancy, non-diagnostic pathologies, false-negative in pathologies) complications (pneumothorax hemoptysis) assessed using multivariable logistic regression analysis. Results Among (median age patients, 66 years [interquartile range, 58–74]; 2715 men), malignancies, specific benign pathologies identified 3054 (65.4%), 1282 (27.5%), 332 (7.1%), respectively. False-negative malignancy occurred 20.5% (236/1153) decidable reference standards. Current was associated (adjusted odds ratio [OR], 1.31; 95% confidence interval [CI]: 1.02–1.69; p = 0.03) (OR, 2.64; CI: 1.32–5.28; 0.006), while heavy (> 1.69; 1.19–2.40; 0.003) 2.12; 1.17–3.92; 0.02). Pneumothorax hemoptysis 21.8% (1018/4668) 10.6% (495/4668) PTNBs, Heavy pneumothorax 1.33; 1.01–1.74; 0.04), 0.64; 0.40–0.99; 0.048) 0.42–0.96; 0.04) inversely hemoptysis. Conclusion Smoking history PTNBs. increased changed complication rates Clinical relevance statement independently Non-diagnostic should be interpreted cautiously or smokers. A patient’s ascertained before PTNB to predict manage complications. Key Points • might contribute Operators need recognize between