A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma

• DOI: 10.1007/s00383-012-3081-y
• Publication Date: 2012-04-09T10:58:18Z
• Authors: Adam S. Brinkman; Bradley Maxfield; Kara Gill; Neha J. Patel; Ankush Gosain
• Keywords: Lipoblastoma; Myxoid liposarcoma

Lipoblastoma is a rare benign neoplasm of embryonic white fatty tissue primarily found in the extremities of children <3 years old (Batanian et al., Cancer Genet Cytogenet 125(1):10-13, 2001; McVay MR et al., J Pediatr Surg 41(6):1067-1071, 2006; Kamal et al., J Pediatr Surg 46(7):E9-E12, 2011). Translocations affecting the 8q11-13 region are commonly reported with lipoblastoma and proper diagnosis requires cytogenetic analysis to distinguish it from malignant myxoid liposarcoma (Miller et al., J Pediatr Surg 32(12):1771-1772, 1997; Morerio et al., Pediatr Blood Cancer 52(1):132-134, 2009). We describe an additional case of lipoblastoma containing a new translocation t(3;8)(p13;q21.1), which has not previously been reported in a healthy asymptomatic child.