STAT trial: stoma or intestinal anastomosis for necrotizing enterocolitis: a multicentre randomized controlled trial

• DOI: 10.1007/s00383-024-05853-3
• Publication Date: 2024-10-29T08:39:27Z
• Authors: Simon Eaton; Niloofar Ganji; Mandela Thyoka; Maher Shahroor; Augusto Zani; Hazel Pleasants-T...; Ali El Ghazzaoui; Jayaram Sivaraj; Stavros Loukogeor...; Paolo De Coppi; Sandra Montedonico; Sanja Sindjic-Ant...; Marija Lukac; James Hamill; Candy Suet Cheng ...; Shireen Anne Nah; Jan Hulscher; Sherif Emil; Aigars Petersen; Rene Wijnen; Cornelius Sloots; David Sigalet; Edward Kiely; Jan F. Svensson; Tomas Wester; Agostino Pierro
• Keywords: Necrotizing Enterocolitis; Stoma (medicine); Multicenter trial; Enterocolitis

Abstract Purpose The STAT trial is a multicenter randomized controlled in 12 centers worldwide aiming to determine the most effective operation for neonates with necrotizing enterocolitis (NEC) requiring intestinal resection: stoma formation (ST) or primary anastomosis (PA). Methods Infants having laparotomy NEC were intraoperatively PA ST if operating surgeon thought that both viable treatment options patient. outcome (duration of parenteral nutrition [PN]) was evaluated by Cox regression. Results Eighty patients recruited from 2010 2019. undergoing finished PN significantly earlier than (hazard ratio vs. 2.38, 95% CI 1.36–4.12 p = 0.004). There no difference mortality between two groups (PA 4/35 8/38 0.35) rate complications further unplanned operations ( n.s.). Multiple more frequent group compared (ST 12/26 5/31, 0.02, Fisher’s Exact test). Conclusion At NEC, when there disease distal resected intestine, should be performed as it enhances recovery reduces risk multiple and does not increase adverse outcomes.