Early postoperative pain as a marker of anastomotic leakage in colorectal cancer surgery

• DOI: 10.1007/s00384-021-03984-w
• Publication Date: 2021-07-17T09:02:57Z
• Authors: Petrus Boström; Johan Svensson; Camilla Brorsson; Martin Rutegård
• Keywords: Pain, Postoperative; Dehiscence; Colon; Kirurgi; Anastomosis, Surgical; Rectum; Anastomotic Leak; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Anastomotic insufficiency; Vital sign; Humans; Surgery; Original Article; Leak; Colorectal Neoplasms; Digestive System Surgical Procedures; Retrospective Studies

Abstract Purpose Even though anastomotic leakage after colorectal surgery is a major clinical problem in need of timely diagnosis, early indicators have been insufficiently studied. We therefore conducted population-based observational study to determine whether the patient’s postoperative pain an independent marker leakage. Methods By combining Swedish Colorectal Cancer Registry and Perioperative Registry, we retrieved prospectively collected data on 3084 patients who underwent for cancer 2014–2017. Postoperative pain, measured with numerical rating scale (NRS), was considered exposure, while reoperation due were outcomes. performed logistic regression evaluate associations, estimating odds ratios (ORs) 95% confidence intervals (CIs), multiple imputation used handle missing data. Results In total, 189 suffered from leakage, whom 121 also needed Moderate or severe (NRS 4–10) associated increased risk (OR 1.69, CI 1.21–2.38), as well 2.17, 1.41–3.32). Severe 8–10) more strongly related 2.38, 1.44–3.93). These associations confirmed multivariable analyses when outcome. Conclusion this retrospective data, post-anaesthesia care unit possibly indicating further diagnostic measures.