Impact of leptin on postoperative peritoneal adhesion formations in colorectal resection

• DOI: 10.1007/s00384-025-04851-8
• Publication Date: 2025-03-15T06:01:16Z
• Authors: Takeru Maekawa; Toru Miyake; Masatsugu Kojima; Soichiro Tani; Takashi Matsunaga; Yusuke Nishina; Sachiko Kaida; Hiromitsu Maehira; Tomoharu Shimizu; Masaji Tani
• Keywords: Peritoneal diseases; Colorectal adenocarcinoma

Postoperative peritoneal adhesion formation (PAF) is a distressing complication. Leptin, secreted by fat tissues, may be associated with PAF. However, the relationships between PAF and leptin are unclear. This study investigated impact of on after colorectal tumor resection. A cecum cauterization mouse model was used to investigate its association leptin. Mice score (AS) evaluated day 7 treatment. The clinical included patients who underwent elective resection temporary ileostomy April 2021 December 2024. AS at time closure. Patients highest quartile were classified into high-AS group; factors examined. An enzyme-linked immunosorbent assay measure human murine serum concentrations. animal experiment revealed that levels postoperative negatively correlated mice ASs (P = 0.0043, r -0.6241). In study, eight had high (27.6%). Visceral mass preoperative higher in group than low-AS group. ratio (postoperative value value) lower multivariate analysis, an independent factor for classifying decrease severe Leptin novel key molecule