Association of NT-proBNP and GDF-15 with markers of a prothrombotic state in patients with atrial fibrillation off anticoagulation

• DOI: 10.1007/s00392-019-01522-x
• Publication Date: 2019-07-06T15:02:36Z
• Authors: Paweł T. Matusik; Barbara Małecka; Jacek Lelakowski; Anetta Undas
• Keywords: GDF15; Plasminogen activator inhibitor-1

We investigated whether growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), levels are associated with a prothrombotic state in atrial fibrillation (AF) compared to N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I (cTnI-hs). In 103 patients AF assessed off anticoagulation (age: 71.0 [65.0–76.0] years; CHA2DS2-VASc score: 4.6 ± 1.7), we measured endogenous thrombin potential (ETP), plasma fibrin clot permeability (Ks, measure of density) lysis time (CLT) other hemostatic parameters, along GDF-15, NT-proBNP, cTnI-hs. GDF-15 positively correlated ETP CLT (r = 0.25, P 0.01 R 0.56, < 0.0001, respectively) but not Ks, von Willebrand factor, thrombin-activatable fibrinolysis inhibitor, plasminogen, antiplasmin or tissue-type plasminogen activator antigen. NT-proBNP showed stronger association 0.60, 0.0001) similar correlation (R 0.53, 0.0001), while cTnI-hs solely 0.01). After adjustment for clinical laboratory was better independent predictor (unstandardized coefficient B 0.009; 95% confidence interval [CI] 0.006–0.012) than (B 0.007; CI 0.004–0.010, (2) 0.51; 0.0001); among the three biomarkers, only an ETP. Elevated independently predict impaired lysability, is key heightened formation AF. Our findings suggest that predictive value could be part attributed their blood alterations.