Subtle signs of atrial cardiomyopathy and left ventricular diastolic dysfunction are associated with reduced cognitive function: results from the Hamburg City Health Study

• DOI: 10.1007/s00392-024-02581-5
• Publication Date: 2024-11-27T07:21:30Z
• Authors: Amelie H. Ohlrogge; Stephan Camen; Lina Nagel; Jan Brederecke; Märit Jensen; Ewgenia Stenmans; Daniel Engler; Christian Schulte; Jan Albrecht; Dora Csengeri; Paulus Kirchhof; Bastian Cheng; Marvin Petersen; Carola Mayer; Christin S. Börschel; Jan-Per Wenzel; Stefan Blankenberg; Simone Kühn; Götz Thomalla; Renate B. Schnabel
• Keywords: Subclinical infection

Abstract Background Atrial fibrillation is associated with cognitive dysfunction. cardiomyopathy has been correlated both entities. We aimed to characterize the association of echocardiographic parameters atrial function and cerebral changes. Methods Participants population-based Hamburg City Health Study underwent in-depth transthoracic echocardiography testing, Animal Naming Test (ANT), Trail Making A (TMT-A) B (TMT-B), 10-word learning test magnetic resonance imaging. Results After excluding individuals stroke or depression, data from 7852 were available. In multi-variable-adjusted regression analyses, E/e’-ratio was level impairment in ANT (− 0.19 per one standard deviation [SD] increase, 95% confidence interval [CI] − 0.36–[− 0.01]) TMT-A (0.01 SD CI 0.003–0.020). Left global peak strain positive performance (-0.01 increase [95% 0.02–(− 0.002)] 0.02 0.03–(− 0.01)], respectively) immediate recall (0.11 0.02–0.20). The positively total periventricular white matter hyperintensity load age- sex-adjusted analyses though statistical significance lost after multi-variable adjustment. Conclusions Subclinical signs left ventricular diastolic dysfunction are impaired tests population. Our provide evidence clinically important cardio-cerebral axis, relating cardiac performance. Graphical abstract