Schwere Polyneuropathie bei primärem Sjögren-Syndrom

• DOI: 10.1007/s00393-020-00821-3
• Publication Date: 2020-05-30T13:03:12Z
• Authors: T. Thiele; T. Seeliger; T. Witte; B. Sander; T. Skripuletz; D. Ernst
• Keywords: Diagnosis, Differential; Male; 0301 basic medicine; Polyneuropathies; 03 medical and health sciences; Sjogren's Syndrome; Biopsy; Humans; Peripheral Nervous System Diseases; Middle Aged

A 64-year-old male patient developed over a period of 20 years a peripheral neuropathy symmetrically affecting the upper and lower limbs. The histological examination of a sural nerve biopsy revealed a severe axonal neuropathy. Despite extensive laboratory investigations including immunological and metabolic tests the origin could not be identified. Finally, a Schirmer test revealed xerophthalmia. A subsequent salivary gland biopsy from the lower lip revealed a grade III lymphocytic inflammation according to Chisholm and Mason and confirmed the diagnosis of Sjögren's syndrome.