The MC4R genetic variants are associated with lower visceral fat accumulation and higher postprandial relative increase in carbohydrate utilization in humans

• DOI: 10.1007/s00394-019-01955-0
• Publication Date: 2019-04-04T05:47:16Z
• Authors: Edyta Adamska-Pat...; Joanna Goscik; Przemyslaw Czajko...; Katarzyna Malisze...; Michał Ciborowski; Anna Golonko; Natalia Wawrusiew...; Anna Citko; Magdalena Waszcze...; Adam Kretowski; Maria Gorska
• Keywords: Melanocortin 4 receptor

The interactions between lifestyle and genetic factors play an important role in obesity development. Mutations melanocortin-4-receptor (MC4R) gene are one of the most common cause monogenic obesity, however, functional effects polymorphic variants near MC4R general populations remain uncertain. aim our study was to analyze whether single nucleotide polymorphisms (SNPs) influence food preferences, physical activity, body fat content distribution, as well fasting postprandial energy expenditure substrates utilization.We genotyped previously identified SNPs: rs17782313, rs633265, rs1350341, rs12970134 927 subjects, who underwent anthropometric, total content, visceral (VAT) subcutaneous adipose tissue (SAT) measurements, daily activity dietary intake analysis. In randomly selected 47 subjects expenditure, carbohydrate lipid utilizations were evaluated state after high-carbohydrate control meals intake.We found significant associations studied SNPs VAT VAT/SAT ratio. Moreover, GG genotype carriers had lowest accumulation (p = 0.012), presented higher relative increase utilization 0.013, p 0.024).We have observed that utilization. We believe may help understand better impact on development, provide personalized prevention/treatment strategies fight against its metabolic consequences.