The influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age: a randomised controlled trial (the iFish Study)

• DOI: 10.1007/s00394-020-02326-w
• Publication Date: 2020-07-28T13:05:09Z
• Authors: Marie C. Conway; Emeir M. McSorley; Maria S. Mulhern; Toni Spence; Edwin van Wijngaa...; Gene E. Watson; Karin Wahlberg; Daniela Pineda; Karin Broberg; Barry W. Hyland; Diego F. Cobice; J. J. Strain; Alison J. Yeates
• Keywords: FADS2; Fatty acid desaturase

Abstract Purpose Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic (ALA) in a pathway involving the desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA their richest source fish preferred. This study investigated effect consumption on PUFA concentrations women childbearing age while stratifying by FADS genotype. The influence lipid profile, markers inflammation oxidative stress was also examined. Methods Healthy ( n = 49) provided buccal swab which analysed for FADS2 genotype (rs3834458; T/deletion). Participants were stratified according to randomised an intervention group receive either no 18), 1 portion 14) or 2 portions 17) (140 g per portion) week period 8 weeks. Serum at baseline post-intervention. Lipid analysed. Results consuming had significantly higher eicosapentaenoic (EPA), docosahexaenoic (DHA) total n-3 PUFA, lower n-6:n-3 ratio compared those (all p < 0.05). Fish did not have significant biomarkers stress, profile current study. Conclusion Consumption has beneficial effects biological age; however, observed. trial registered www.clinicaltrials.gov (NCT03765580), December 2018.