Effects of a single phosphate-enriched test meal on inflammasome activity and postprandial inflammatory markers in healthy subjects

• DOI: 10.1007/s00394-023-03306-6
• Publication Date: 2024-01-04T09:02:34Z
• Authors: Anika Nier; Christof Ulrich; Christin Volk; Marie-Charlotte W...; Corinna Brandsch; Monika Wensch-Dor...; Matthias Girndt; Gabriele I. Stangl
• Keywords: ddc:610; 0303 health sciences; Interleukin-6; Inflammasomes; 610; Original Contribution; Postprandial Period; Healthy Volunteers; Interleukin-10; Phosphates; 03 medical and health sciences; C-Reactive Protein; Glucose; Cytokine Receptor gp130; Leukocytes, Mononuclear; Humans

Abstract Purpose The consumption of highly processed food is often associated with a high intake inorganic phosphate. Hyperphosphatemia accompanied by an inflammatory status in patients chronic kidney disease. However, the immune response to phosphorus healthy individuals largely unknown. Therefore, aim present study was evaluate effect single phosphate-enriched meal on inflammasome activity and plasma levels markers. Methods analysis included 28 participants who received dose either 700 mg or placebo test meal. At baseline, 4 8 h post-meal, interleukin (IL)-6, IL-1β, IL-10, c-reactive protein (CRP), soluble IL-6 receptor (sIL-6R) glycoprotein 130 (sgp130) were determined. baseline peripheral blood mononuclear cells isolated assess activity. Subsequently, phosphate without glucose IL-1β gene expression secretion U937 monocytes examined. Results While both groups showed marked postprandial increase levels, neither IL-6, CRP, sIL-6R, sgp130 nor affected compared placebo. In cells, there also no expression, but addition increased it. Phosphate, however, reduced these cells. Conclusion Postprandial markers not dietary markedly which appears be metabolic rather than pro-inflammatory phenomenon. Trial registration number ClinicalTrials.gov, NCT03771924, date registration: 11th December 2018, retrospectively registered.