CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

• DOI: 10.1007/s00401-020-02188-w
• Publication Date: 2020-07-08T05:33:39Z
• Authors: Philipp Sievers; Thomas Hielscher; Daniel Schrimpf; Damian Stichel; David E. Reuss; Anna S. Berghoff; Marian C. Neidert; Hans-Georg Wirsching; Christian Mawrin; Ralf Ketter; Werner Paulus; Guido Reifenberger; Katrin Lamszus; Manfred Westphal; Nima Etminan; Miriam Ratliff; Christel Herold-M...; Stefan M. Pfister; David T. W. Jones; Michael Weller; Patrick N. Harter; Wolfgang Wick; Matthias Preusser; Andreas von Deimling; Felix Sahm
• Keywords: Genes, p16; Homozygote; 2804 Cellular and Molecular Neuroscience; 610 Medicine & health; 10040 Clinic for Neurology; 3. Good health; 2734 Pathology and Forensic Medicine; 03 medical and health sciences; 2728 Neurology (clinical); 0302 clinical medicine; Correspondence; Meningeal Neoplasms; Humans; Gene Deletion [MeSH] ; Homozygote [MeSH] ; Genes, p16/physiology [MeSH] ; Meningeal Neoplasms/genetics [MeSH] ; Humans [MeSH] ; Sequence Deletion/genetics [MeSH] ; Pathology ; Meningioma/genetics [MeSH] ; Neurosciences ; Cyclin-Dependent Kinase Inhibitor p16/genetics [MeSH] ; Correspondence; Meningioma; Cyclin-Dependent Kinase Inhibitor p16; Gene Deletion; Sequence Deletion

Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved treatment and reperfusion strategies, the uncompensated cardiomyocyte loss during injury and disease results in cardiac remodeling and subsequent heart failure. The promising field of regenerative medicine aims to restore both the structure and function of damaged tissue through modulation of cellular processes and regulatory mechanisms involved in cardiac cell cycle arrest to boost cardiomyocyte proliferation. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are functional RNA molecules with no protein-coding function that have been reported to engage in cardiac regeneration and repair. In this review, we summarize the current understanding of both the biological functions and molecular mechanisms of ncRNAs involved in cardiomyocyte proliferation. Furthermore, we discuss their impact on the structure and contractile function of the heart in health and disease and their application for therapeutic interventions.