Adaptive structural changes in the motor cortex and white matter in Parkinson’s disease

• DOI: 10.1007/s00401-022-02488-3
• Publication Date: 2022-09-02T11:21:14Z
• Authors: YuHong Fu; Liche Zhou; Hongyun Li; Jen-Hsiang T. Hsiao; Binyin Li; Onur Tanglay; Andrew D. Auwyang; Elinor Wang; Jieyao Feng; Woojin S. Kim; Jun Liu; Glenda M. Halliday
• Keywords: Corticospinal tract

Parkinson's disease (PD) is a movement disorder characterized by the early loss of nigrostriatal dopaminergic pathways producing significant network changes impacting motor coordination. Recently three stages PD have been proposed (a silent period when begins, prodromal with subtle focal manifestations, and clinical PD) evidence that cortex abnormalities occur to produce PD[8]. We directly assess structural in primary corticospinal tract using parallel analyses longitudinal cross-sectional pathological cohorts thought represent different PD. 18F-FP-CIT positron emission tomography features identified patients idiopathic rapid-eye-movement sleep behaviour (n = 8) developed signs Longitudinal diffusion tensor imaging before after development showed higher fractional anisotropy compared controls, indicating adaptive networks concert dopamine loss. Histological white matter underlying progressive disorientation axons segmental replacement neurofilaments α-synuclein, enlargement myelinating oligodendrocytes increased density their precursors. There was no neurons or late pathologically confirmed although there were cortical increases neuronal neurofilament light chain myelin proteins association α-synuclein accumulation. Our results collectively provide direct impact on its output begins stage These become considerable as advances potentially contributing