Astroglial calcium signaling and homeostasis in tuberous sclerosis complex

• DOI: 10.1007/s00401-024-02711-3
• Publication Date: 2024-02-28T20:02:42Z
• Authors: Alessia Romagnolo; Giulia Dematteis; Mirte Scheper; Mark J. Luinenburg; Angelika Mühlebner; Wim Van Hecke; Marcello Manfredi; Veronica De Giorgis; Simone Reano; Nicoletta Filigheddu; Valeria Bortolotto; Laura Tapella; Jasper J. Anink; Liesbeth François; Stefanie Dedeurwa...; James D. Mills; Armando A. Genazzani; Dmitry Lim; Eleonora Aronica
• Keywords: Homeostasis; Calcium Signaling

Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in various organs, including brain, and often accompanied epilepsy, neurodevelopmental comorbidities intellectual disability autism. A key hallmark TSC hyperactivation mechanistic target rapamycin (mTOR) signaling pathway, which induces alterations cortical metabolic processes astrocytes, among other cellular functions. These changes could modulate seizure susceptibility, contributing to progression epilepsy its associated comorbidities. Epilepsy dysregulation calcium (Ca