P53 staining index and zonal staining patterns in actinic keratoses

• DOI: 10.1007/s00403-020-02104-y
• Publication Date: 2020-07-08T13:03:43Z
• Authors: Sanja Javor; Giulia Gasparini; Chiara Maria Biatta; Emanuele Cozzani; Francesco Cabiddu; Jean Louis Ravetti; Valerio Gaetano V...; Aurora Parodi
• Keywords: Male; Original Paper; Skin Neoplasms; Ultraviolet Rays; Biopsy; Actinic keratosis; Immunohistochemistry; Non-melanoma skin cancer; p53; Squamous cell carcinoma; Age Factors; Aged; Biomarkers; Biopsy; Carcinoma, Squamous Cell; Disease Progression; Epidermis; Face; Female; Humans; Keratosis, Actinic; Male; Middle Aged; Mutation; Retrospective Studies; Severity of Illness Index; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays; Age Factors; Middle Aged; Severity of Illness Index; Keratosis, Actinic; 03 medical and health sciences; 0302 clinical medicine; Face; Mutation; Carcinoma, Squamous Cell; Disease Progression; Humans; Female; Epidermis; Tumor Suppressor Protein p53; Biomarkers; Aged; Retrospective Studies

Abstract Actinic keratoses (AKs) are common dysplastic lesions resulting from chronic excessive ultraviolet exposure. Neither the clinical grade of thickness nor histological dysplasia seems valid predictors aggressive potential AKs. Instead, mutational status in AKs appears to predict well course. TP53 gene mutations result a non-functional protein resistant degradation, thus immunohistochemical staining for p53 can suggest mutation status. Increased was associated with progression AK squamous cell carcinoma. To investigate how intensity (p53 index) varies according body site, subtype and Secondly, we sought distribution epidermal layers (zonal patterns). index greater than 50% 90.7% significantly higher older age ( p < 0.0093) facial compared other areas = 0.03). A significant correlation between observed 0.006) zonal pattern 0.003). No differences among various types were observed. grade. All AKs, independently their appearance, should be treated but special attention is required on severely photodamaged skin face patients.