Maternal left ventricular function and adverse neonatal outcomes in women with cardiac disease

• DOI: 10.1007/s00404-022-06635-9
• Publication Date: 2022-06-03T07:04:03Z
• Authors: Elizabeth J. Eggl...; Catriona J. Bhagra; Charlotte J. Patient; Mark Belham; Janet Pickett; Catherine E. Aiken
• Keywords: Global longitudinal strain; Fetal Growth Retardation; Heart Diseases; Cardiomyopathy; Placenta; Pregnancy Trimester, Third; Left ventricular function; Infant, Newborn; Ventricular Function, Left; Ultrasonography, Prenatal; Maternal-Fetal Medicine; Cardiac disease; 3. Good health; Neonatal outcomes; Pregnancy; Humans; Female; Cardiac Output

Abstract Purpose To evaluate the relationship between maternal left ventricular systolic function, utero-placental circulation, and risk of adverse neonatal outcomes in women with cardiac disease. Methods 119 managed pregnancy heart clinic (2019–2021) were identified. Women classified by their primary condition. Adverse were: low birth weight (< 2500 g), small-for-gestational-age 10th birth-weight centile), pre-term delivery 37 weeks’ gestation), fetal demise (> 20 gestation). Parameters function (global longitudinal strain, radial ejection fraction, average S’, output) calculated pulsatility index was recorded from last growth scan. Results occurred 28 neonates (24%); most frequently valvular disease ( n = 8) cardiomyopathy 7). Small-for-gestational-age common p 0.016). Early S’ 0.03), late 0.02), output 0.008) significantly lower than those healthy neonates. There a significant association centile global strain 0.04) 0.0002) pregnancy. Pulsatility highest 0.007), correlated < 0.0001) 0.03) Conclusion may not tolerate cardiovascular adaptations required during to support growth. associated reduced higher index. The impaired is supported insufficient circulation.