Intratympanic gentamycine for Ménière’s disease: is there a selective vestibulotoxic effect?

• DOI: 10.1007/s00405-020-05901-3
• Publication Date: 2020-03-30T13:03:42Z
• Authors: András Molnár; Stefani Maihoub; Anita Gáborján; László Tamás; Ágnes Szirmai
• Keywords: Audiogram

Abstract Purpose The aim of our study is to investigate the effectiveness and safety treatment, based on vertigo diaries pure tone audiograms. Methods complete medical documentation 105 definite patients suffering from Ménière’s disease was analyzed. In studied group, nine were treated with intratympanic gentamycine. Long-term follow-up carried out, using diaries, letters, anamnestic data, Audiometric results complaints before after treatment contrasted IBM SPSS V24 software. Results Based analysis, attacks appeared significantly less often gentamycine [ p < 0.001; Odds ratio 0.003 (95% CI 0.001–0.012)], which confirms efficacy therapy. Pure stages application Mann–Whitney U test. When comparing audiometric long-term follow-ups by logistic regression, a statistically significant difference observed between not groups = 0.141 0.064–0.313)], survivorship curve hearing impairment more common in group also supports results. non-parametric test, there no ( 0.84) pure-tone control those Conclusion Our indicate that effective controlling attacks, higher risk for loss than case spontaneous progression disorder.