Polygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkers

• DOI: 10.1007/s00406-023-01591-0
• Publication Date: 2023-05-05T10:02:16Z
• Authors: Elina J. Reponen; Thor Ueland; Jaroslav Rokicki; Francesco Bettella; Monica Aas; Maren C. F. Werner; Ingrid Dieset; Nils E. Steen; Ole A. Andreassen; Martin Tesli
• Keywords: Polygenic risk score

Individuals with schizophrenia and bipolar disorder are at an increased risk of cardiovascular disease (CVD), a range biomarkers related to CVD have been found be abnormal in these patients. Common genetic factors putative underlying mechanism, alongside lifestyle antipsychotic medication. However, the extent which altered involved is unknown. In sample including 699 patients schizophrenia, 391 disorder, 822 healthy controls, we evaluated 8 biomarkers, BMI, fasting plasma levels from subsample. Polygenic scores (PGRS) were obtained genome-wide associations studies (GWAS) Psychiatric Genomics Consortium. The used as outcome variables linear regression models PGRS predictors, age, sex, diagnostic category, batch 10 principal components covariates, controlling for multiple testing by Bonferroni correction number independent tests. Bipolar was significantly (p = 0.03) negatively associated BMI after correction, nominally BMI. There no other significant between or PGRS, investigated biomarkers. Despite psychotic disorders, only negative association This has previously shown warrants further exploration.