Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder

• DOI: 10.1007/s00406-024-01780-5
• Publication Date: 2024-03-16T14:01:35Z
• Authors: Mu-Hong Chen; Ya-Mei Bai; Ju-Wei Hsu; Kai-Lin Huang; Shih-Jen Tsai
• Keywords: Proinflammatory cytokine; Depression

Abstract Whether proinflammatory cytokine dysregulation and cognitive dysfunction are associated with suicidal symptoms in adolescents young adults major depressive disorder (MDD) remains uncertain. We assessed the function levels of 43 51 patients aged 15–29 years MDD severe mild symptoms, respectively, as well those 85 age- sex-matched healthy controls. Specifically, we measured serum C-reactive protein, tumor necrosis factor-α (TNF-α), interleukin-2, interleukin-6 by using working memory go/no-go tasks. The severity patients’ was based on Item 10 Montgomery–Åsberg Depression Rating Scale; scores ≤ 2 ≥ 4 indicated respectively. had higher protein ( p = .019) TNF-α .002) than did or number errors committed .001) significantly After adjusting for nonsuicidal observed to be positively .050) task .021). Compared greater cytokines inferior MDD.