Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study

• DOI: 10.1007/s00415-017-8635-4
• Publication Date: 2017-10-23T21:22:00Z
• Authors: Sara Mariotto; Sergio Ferrari; Salvatore Monaco; Maria Donata Bene...; Kathrin Schanda; Daniela Alberti; Alessia Farinazzo; Ruggero Capra; Chiara Mancinelli; Nicola De Rossi; Roberto Bombardi; Luigi Zuliani; Marco Zoccarato; Raffaella Tanel; Adriana Bonora; Marco Turatti; Massimiliano Cala...; Alberto Polo; Antonino Pavone; Luisa Grazian; GianPietro Sechi; Elia Sechi; Daniele Urso; Rachele Delogu; Francesco Janes; Luciano Deotto; Morena Cadaldini; Maria Rachele Bia...; Gaetano Cantalupo; Markus Reindl; Alberto Gajofatto
• Keywords: Myelin oligodendrocyte glycoprotein; Neuromyelitis Optica; Subclass; Optic neuritis; Acute disseminated encephalomyelitis

Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare clinical and laboratory findings observed cohort MOG-Ab seropositive seronegative cases describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or testing were analysed between March 2014 May 2017. The presence AQP4-Ab was determined using cell-based assay. A live cell immunofluorescence assay used detection MOG-IgG analysis. Among 454 samples, 29 excluded due positivity or final demonstration disorder not compatible MOG-Ab. obtained data 154 out 425 cases. Of these, 22 subjects resulted positive. positive mainly characterised by involvement optic nerve spinal cord. Half presented relapses recovery usually partial. Brain MRI heterogeneous while short lesions prevalent observation on cord MRI. titre decreased non-relapsing In all cases, we IgG1 antibodies, which predominant most subjects. IgG2 (5/22), IgG3 (9/22) IgG4 (3/22) also detectable. confirm that MOG-Ab-related syndromes have distinct features spectrum conditions, possible role different subclasses this condition.