Parkinson’s disease laterality: a 11C-PE2I PET imaging study

• DOI: 10.1007/s00415-020-10204-y
• Publication Date: 2020-09-02T16:03:43Z
• Authors: Andreas-Antonios ...; Zhou Zeng; Nicholas P. Lao-Kaim; Antonio Martin-Ba...; Paola Piccini; ; Roger A. Barker; Krista Farrell; Natalie Valle Guzman; Xiaoling He; Stanley E. Lazic; Sarah Moore; Robert Morris; Pamela Tyers; Ruwani Wijeyekoon; Danielle Daft; Sam Hewitt; Biswas Dayal; Thomas Foltynie; Zenobia Kefalopoulou; Philipp Mahlknecht; Hjalmar Bjartmarz; Anders Björklund; Olle Lindvall; Jenny Nelander-Wa...; Malin Parmar; Gesine Paul; Hakan Widner; Alistair Church; Stephen Dunnett; Kathryn Peall; Anne Rosser; Jean Marc Gurruchaga; Stéphane Palfi; Tobias Piroth; Christian Winkler
• Keywords: Dopamine Plasma Membrane Transport Proteins; 03 medical and health sciences; Original Communication; 0302 clinical medicine; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Humans; Parkinson Disease; Longitudinal Studies

AbstractAsymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.